Table 2. Relative Abundance classes of urine protein biomarkers.
Class 1: 100 ng/ml–>10 ug/ml | Class 2: 10 ng/ml –100 ng/ml | Class 3: 1 ng/ml –10 ng/ml | Class 4: Non-standard units | ||||
Biomarker | Protein Family | Biomarker | Protein Family | Biomarker | Protein Family | Biomarker | Protein Family |
THP | glycoprotein | IGFBP-7 | growth modulator | Transthyretin | carrier protein | FSH | hormone |
HSA | plasma Protein | HE4 | glycoprotein | Kallikrein 10 | serine protease | LH | hormone |
SCC | glycoprotein | PSA | serine protease | Apolipoprotein AII | apolipoprotein | CA 15-3 | cancer antigen |
OPN | cytokine | EGF | growth factor | Apolipoprotein E | apolipoprotein | CA-125 | cancer antigen |
Calbindin | calcium binding | MPO | peroxidase | NSE | enolase | CA 19-9 | cancer antigen |
Clusterin | glycoprotein | Cystatin C | Protease Inhibitor | M-CSF | cytokine | ||
Mammaglobin | glycoprotein | β2-Microglobulin | MHC-1 component | TIMP-2 | MMP inhibitor | ||
α1-Antitrypsin | protease Inhibitor | IGFBP-3 | growth modulator | Fibronectin | extracellular matrix | ||
fPSA | protease | ANGPTL4 | glycoprotein | ||||
Thrombospondin | Anti-angiogenesis | GSTα | enzyme | ||||
LOX-1 | membrane receptor | sTNFRII | secreted receptor | ||||
GST π | enzyme | MMP-8 | MMP | ||||
TFF-3 | gut secretion | Complement C3 | complement | ||||
C-Peptide | peptide | CEA | glycoprotein | ||||
Thrombomodulin | receptor | sICAM-1 | adhesion molecule | ||||
MDA-LDL | lipoprotein | Keratin-1,10,11 | structural protein | ||||
Adiponectin | hormone | Cortisol | hormone (steroid) | ||||
Cathepsin D | protease | Angiogenin | ribonuclease | ||||
Apolipoprotein A1 | apolipoprotein | Complement H | complement | ||||
α-2-Macroglobulin | plasma Protein | Involucrin | envelope protein | ||||
Apolipoprotein B | apolipoprotein | ||||||
sgp130 | cytokine | ||||||
MMP-7 | MMP | ||||||
MMP-9 | MMP | ||||||
H-FABP | growth inhibitor | ||||||
sVCAM-1 | adhesion molecule | ||||||
PBEF | enzyme | ||||||
Complement C4 | complement | ||||||
Keratin-6 | structural protein | ||||||
sTNFRI | secreted receptor | ||||||
Cytokeratin 19 | intermediate filament | ||||||
Endostatin | extracellular signalling | ||||||
OC | hormone | ||||||
NCAM | adhesion molecule | ||||||
Biomarkers within each class listed in order of decreasing relative abundance; Biomarkers in bold indicate high molecular weight (>70 kDa).