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. 2013 May 28;8(5):e64010. doi: 10.1371/journal.pone.0064010

Figure 3. Inhibitory activity of LabyA1 against the cell-to-cell HIV transmission.

Figure 3

(A) Light microscopical pictures of (a) persistently HIV-infected HUT-78/IIIB cells, (b) non-infected CD4+ target T cells, (c) giant cell formations after coculture of HUT-78/IIIB and SupT1 cells, (d) coculture of HUT-78/IIIB and SupT1 cells in the presence of 24 µM LabyA1, (e) 4.8 µM LabyA1 and (f) 0.96 µM LabyA1. One representative experiment is shown. Magnification x10/0.25. (B) Percentage of living SupT1 T cells after 24 h of coculture with HUT-78/IIIB cells in the presence of LabyA1. To discriminate SupT1 T cells from HUT-78/IIIB cells, the expression of the CD28 marker was measured by flow cytometry. The mean ± SEM out of 4 independent experiments is shown.