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. 2013 May 28;8(5):e63848. doi: 10.1371/journal.pone.0063848

Figure 11. The proportion of mitotic cells that express GFAP in the prenatal macaque occipital cortex during neurogenic stages (E50, E65, E80, E100) and one postneurogenic stage (E150).

Figure 11

Mitoses were identified in each proliferative zone and cortical layer by 4A4 immunoreactivity, PH3 immunoreactivity and/or condensed chromatin with DAPI. ( A ) 100% of all mitotic cells at the ventricular surface of the dorsal neocortex expressed GFAP during neurogenic stages. No surface dividing cells were detected at E150. ( B ) The majority of mitotic cells expressed GFAP in the inner subventricular zone (iSVZ) during cortical neurogenesis. The iSVZ was largely absent at E150. ( C ) The majority of mitotic cells in the outer SVZ (oSVZ) expressed GFAP during neurogenic stages of development. The oSVZ was not present at E50, and the proportion of mitotic cells that expressed GFAP at E150 fell to 25%. ( D ). The majority of mitotic cells in extra-germinal zones expressed GFAP during neurogenesis, but not during post-neurogenic stages. SP, subplate; CP, cortical plate; MZ, marginal zone.