Table 3. Differential gene expression in PAI-1 knockout hearts and kidneys.
| GeneSymbol | Gene Name Upregulated (A) | p value |
| TIMP1 | Tissue inhibitor of metalloproteinase 1 | 0.02 |
| Dbp | D site albumin promoter binding protein | 0.01 |
| Scx | Scleraxis | 0.001 |
| Col3A1 | Collagen, type III, alpha 1 | 0.007 |
| MMP23 | Matrix metallopeptidase 23 | 0.01 |
| Igfbp6 | Insulin-like growth factor binding protein 6 | 0.005 |
| Klf6 | Kruppel-like factor 6 | 0.00005 |
| Notch4 | Notch gene homolog 4 | 0.0003 |
| Ebf2 | Early B cell factor 2 | 0.00005 |
| Timp2 | Tissue inhibitor of metalloproteinase 2 | 0.008 |
| Egr1 | Early growth response 1 | 0.0002 |
| Dusp1 | Dual specificity phosphatase 1 | 0.00001 |
| Loxl1 | Lysyl oxidase-like 1 | 0.02 |
| il6st | Interleukin 6 signal transducer | 0.0002 |
| Gene Symbol | Gene Name Downregulated (B) | p value |
| Xbp1 | X-box binding protein 1 | 0.0005 |
| Stx7 | Syntaxin 7 | 0.003 |
| Map3k11 | Mitogen activated protein kinase kinase kinase 11 | 0.0001 |
| Zfp523 | Zinc finger protein 523 | 0.00001 |
| Dad1 | Defender against cell death 1 | 0.0001 |
| Cdk8 | Cyclin-dependent kinase 8 | 0.00004 |
Genes upregulated (>1.5 fold) in knockout hearts compared to knockout kidneys (unique) (A). Genes downregulated (<1.5 fold) in knockout hearts compared to knockout kidneys (unique) (B).