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. 2013 May 28;8(5):e63638. doi: 10.1371/journal.pone.0063638

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© 2013 Hemmingsen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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ASCs exposed to adipogenic stimuli in AM secrete an unknown factor acting as a positive regulating signal in the differentiation process. This positive cell-released signaling factor is removed during perfusion conditions with AM thereby suppressing differentiation. Differentiation can be restored by perfusion with the factor contained in CM. The auto/paracrine signaling factor is acting in the early phase of differentiation upstream of the transcription factors C/EBPβ and C/EBPδ.