Table 1. MICs of the SCAR compounds acting on MTB H₃₇Rv under various conditions and on drug-resistant variants under normal conditions.

Compound	MIC (µM)
	Normal	pH 6	Protein Binding		Drug Resistant Variants*
			4% BSA	10% FBS	rRMP	rINH	rSM	rKM
SCAR1	1.2	2.4	2.5	1.3	2.6	2.5	3.3	2.5
SCAR2	1.2	2.2	2.0	1.3	3.1	2.5	3.3	2.5
SCAR4	1.4	2.7	3.5	1.9	4.2	2.8	4.2	2.9
SCAR5	0.8	1.7	1.7	0.8	1.8	1.9	1.9	2.0
SCAR6	1.6	4.9	3.2	3.1	5.0	6.3	6.6	6.6
SCAR7	2.1	2.7	2.8	2.5	5.0	4.0	5.4	5.4
Standard Drug
RMP	0.1	0.2	0.1	0.1	>2	n.d.	n.d.	n.d.
INH	0.1	0.2	0.3	0.2	n.d.	>4	n.d.	n.d.
SM	0.5	0.8	0.9	1.3	n.d.	n.d.	>7.9	n.d.
KM	4.1	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	>10.2

Normal conditions – those recommended by the manufacturer (pH = 6.8).

^*rRMP - H₃₇Rv -rifampicin-resistant (ATCC 35838).

^*rINH - H₃₇Rv-isoniazid-resistant (ATCC 35822).

^*rSM - H₃₇Rv-streptomycin-resistant (ATCC 35820).

^*rKM - H₃₇Rv -kanamycin-resistant (ATCC 35827).

n.d. - not determined.