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. 2013 May 24;5(4):412–426.

Figure 1.

Figure 1

Overexpression of human SIRT1 in adipose tissue of mice attenuates the deterioration of insulin sensitivity with ageing. A: Fasting (16 hours) body weights of WTM and AWSM at different ages. B: Fasting (16 hours) serum insulin concentrations of WTM and AWSM at different ages. C: Intraperitoneal glucose tolerance tests (ipGTT) for WTM and AWSM at different ages. The area under curve (AUC) was calculated and shown in the right panel. Black and red curves represent WTM and AWSM, respectively. D: Insulin tolerance tests (ITT) for WTM and AWSM at different ages. The area under curve (AUC) was calculated and shown in the right panel. *, P<0.05 compared with WTM control group (n=10).