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. 2013 May 24;5(4):412–426.

Figure 5.

Figure 5

Biotin treatment abolishes hSIRT1-mediated beneficial metabolic effects in adipose tissue and skeletal muscle of AWSM. A: Evaluation of total ACC expression (left) and ACC activity (right) in epididymal fat of vehicle- or biotin-treated WTM and AWSM. B: Co-immunoprecipitation (IP) analysis of SIRT1-ACC interaction and ACC acetylation in epididymal fat of vehicle- or biotin-treated WTM and AWSM. C: Comparison of ATGL mRNA expression (left) and lipolysis rate (right) in epididymal (epi) fat of biotin-treated WTM and AWSM. D: Left: The ratios of NAD/NADH in epididymal (epi) fat and skeletal muscle of biotin-treated WTM and AWSM; Right: Comparison of fatty acid oxidation rate in skeletal muscle of biotin-treated WTM and AWSM. *, P<0.05 compared with corresponding WTM control group (n=5-6).