. 2013 Apr 25;14(2):782–793. doi: 10.1208/s12249-013-9964-y

Table III.

Mathematical Modeling and Drug Release Kinetics from the Investigated T HCl-Loaded NPs

Formulae	Zero order plot linearity coefficient (R ²)	First order plot linearity coefficient (R ²)	Higuchi’s plot linearity coefficient (R ²)	The best fitting model	P _8 h (%)
F1	0.975	0.964	0.918	Zero order	45.28
F2	0.923	0.908	0.869	Zero order	46.96
F3	0.862	0.830	0.756	Zero order	48.61
F4	0.957	0.947	0.892	Zero order	39.05
F5	0.945	0.942	0.941	Zero order	44.19
F6	0.939	0.934	0.933	Zero order	46.08
F7	0.958	0.964	0.981	Higuchi diffusion	26.51
F8	0.964	0.979	0.990	Higuchi diffusion	41.14
F9	0.857	0.894	0.929	Higuchi diffusion	43.92
F10	0.942	0.938	0.929	Zero order	47.55
F11	0.965	0.963	0.937	Zero order	48.62
F12	0.979	0.969	0.969	Zero order	60.21
F13	0.974	0.973	0.953	Zero order	45.46
F14	0.967	0.966	0.949	Zero order	48.5
F15	0.899	0.870	0.820	Zero order	49.64
F16	0.956	0.965	0.983	Higuchi diffusion	35.14
F17	0.898	0.910	0.961	Higuchi diffusion	36.6
F18	0.924	0.919	0.926	Higuchi diffusion	37.75