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The Pharmacokinetic Parameters of T HCl Following Ocular Instillation of the Oily Drug Solution and F5 NP Suspension to Rabbits (Mean ± SD, n = 5)
| Formulae | C max (ng/ml) | T max a (h) | AUC(0–8) (ng h−1 ml−1) | MRT(0–8) (h) | Increase in bioavailability (folds) |
|---|---|---|---|---|---|
| Oily solution | 79.347 ± 54.400 | 1 | 178.425 ± 108.478 | 2.264 ± 0.768 | – |
| F5 NP suspension | 57.310 ± 33.029 | 2 | 295.646 ± 120.474 | 4.849 ± 0.596 | 1.657 ± 0.776 |
aMedian
