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Particle Size, Polydispersity Index, and Solubility of Indomethacin Nanosuspensions Milled with Different Sized Milling Balls (n = 3)
| Milling ball diameter (mm) | Size (nm) | PI | Solubility (μg/ml) | |
|---|---|---|---|---|
| pH 1.2 | pH 5.0 | |||
| 1 | 340 ± 4 | 0.24 ± 0.06 | 1.29 ± 0.03 | 21.23 ± 0.19 |
| 5 | 560 ± 11 | >0.7 | 1.23 ± 0.06 | 19.25 ± 0.39 |
| 10 | 1,300 ± 111 | >0.7 | 1.15 ± 0.01 | 18.06 ± 0.43 |
PI polydispersity index
