Table I.
Physicochemical Parameters and % Moisture Uptake for the In Situ Gelling Nasal Inserts of Salbutamol Sulfate
| Formulation | Thickness (μm ± SD) (n = 10) | Drug content/insert (mg ± SD) (n = 6) | Weight (mg ± SD) (n = 10) | Surface pH (n = 2) | % Moisture uptakea |
|---|---|---|---|---|---|
| CMC Na | 15.1 ± 0.9 | 4.2 ± 1.3 | 18.5 ± 0.8 | 6–7 | 16.9 ± 0.02 |
| HPMC | 20.3 ± 0.5 | 4.3 ± 0.2 | 16.4 ± 1.4 | 6–7 | 12.8 ± 0.03 |
| AL | 26.6 ± 0.7 | 3.9 ± 0.5 | 19.8 ± 3.6 | 6–7 | 22.9 ± 0.02 |
| CH | 27.1 ± 0.8 | 4.1 ± 0.7 | 27.5 ± 0.9 | 5–6 | 7.0 ± 0.03 |
HPMC hydroxypropyl methylcellulose, CMC Na carboxymethylcellulose sodium, AL sodium alginate, CH chitosan, SD standard deviation
aMoisture uptake by the in situ gelling nasal inserts after 48 h at room temperature and 79.3% RH