Table I.
Solvent | CD | K C (M−1) | Final pH | S 0 (mg/ml) | S max (mg/ml) | ES |
---|---|---|---|---|---|---|
Watera | βCD | 101 ± 4 | 6.6 | 0.42 ± 0.02 | 0.93 ± 0.03 | 2 |
Buf. pH 2 | 40.4 ± 0.4 | 2.1 | 1.1 ± 0.2 | 1.63 ± 0.02b | 1.5 | |
Buf. pH 8 | 29.4 ± 0.4 | 8.4 | 1.93 ± 0.06 | 2.6 ± 0.1b | 1.3 | |
Water | MβCD | 56 ± 1 | 6.4 | 0.42 ± 0.02 | 7.7 ± 0.1c | 18 |
Buf. pH 2 | 39 ± 3 | 2.2 | 1.1 ± 0.2 | 4.4 ± 0.1d | 4 | |
Buf. pH 8 | 39 ± 5 | 8.4 | 1.93 ± 0.06 | 3.5 ± 0.5d | 2 |
aZoppi et al. (15)
bSMT solubility in βCD (13.2 mM) solutions
cSMT solubility in MβCD (105 mM) solutions
dSMT solubility in MβCD (85 mM) solutions