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. 2013 Apr 19;14(2):727–735. doi: 10.1208/s12249-013-9958-9

Table I.

Data from the Phase-Solubility Curves of SMT with βCD and MβCD at Different pH Values

Solvent CD K C (M−1) Final pH S 0 (mg/ml) S max (mg/ml) ES
Watera βCD 101 ± 4 6.6 0.42 ± 0.02 0.93 ± 0.03 2
Buf. pH 2 40.4 ± 0.4 2.1 1.1 ± 0.2 1.63 ± 0.02b 1.5
Buf. pH 8 29.4 ± 0.4 8.4 1.93 ± 0.06 2.6 ± 0.1b 1.3
Water MβCD 56 ± 1 6.4 0.42 ± 0.02 7.7 ± 0.1c 18
Buf. pH 2 39 ± 3 2.2 1.1 ± 0.2 4.4 ± 0.1d 4
Buf. pH 8 39 ± 5 8.4 1.93 ± 0.06 3.5 ± 0.5d 2

aZoppi et al. (15)

bSMT solubility in βCD (13.2 mM) solutions

cSMT solubility in MβCD (105 mM) solutions

dSMT solubility in MβCD (85 mM) solutions