Table II.
Pharmacological inhibitors
| Action | Target | Drug (Company) | Description | Ref. |
|---|---|---|---|---|
| Suppression of IL-1β production | ||||
| Caspase-1 inhibition | Caspase-1 | Pranalcasan (Aventis/Vertex) | VX-740; VX-765 | 70 |
| IL-1 β posttranslational processing | Unknown | CP424174, CP412245 (Pfizer) | Diarylsulphonyl urea | 70 |
| IL-1 β production inhibitor | Unknown | CJ14877, CJ14897 (Pfizer) | Pyridine-2-carboxylates | 70 |
| Unknown | LL-Z1217a (Pfizer) | Terpenoid lactone | 70 | |
| Suppression of IL-1 β release | ||||
| IL-1 β release inhibitors | Unknown | CP424174 (Pfizer) | Diarylsulphonyl urea | 70 |
| Neutralization of secreted IL-1 β | IL-1 | Anakinra (Kineret, Amgen) | rhuIL-1Raa | 70 |
| IL-1 | IL-1trap (Regeneron/Novartis) | Human IL-1R1:IgG1 protein | 70 | |
| IL-1 | CDP-484 (Celltech) | PEGylated Ab | 70 | |
| Inhibition of IL-1R signal transduction | ||||
| MyD88 inhibitors | MyD88 | Hydrocinnamoyl-L-valyl pyrrolidine15 | MyD88 mimic | 70, 73 |
| ST2825 (Sigma-Tau)b | Peptidomimetic | 74 | ||
| IRAK-4 inhibitors | IRAK-4 | Names unavailableb | Amides, imidazo [1,2-a] pyridine compounds | 76-78 |
a
Recombinant human IL-1Ra.
b
May also inhibit IL-18R and TLR signal transduction.