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. Author manuscript; available in PMC: 2013 May 29.
Published in final edited form as: Nat Rev Genet. 2012 Oct 9;13(11):795–806. doi: 10.1038/nrg3317

Figure 2. The role of the environment in evolutionary adaptation.

Figure 2

A multitude of environmental factors may shape the evolutionary processes within a single cancer. Blue and purple bubbles represent successive cancer clones, the expansion of which is altered by directly mutagenic factors (grey arrows) and non-mutagenic factors (black arrows).