Table 3.
Distribution of Clinically Significant DNA Variants Identified by Gene
Gene | No. of Patients Tested | Mutations,* % (n) |
---|---|---|
MYH7 | 241 | 6.6 (16) |
TNNT2 | 241 | 3.7 (9) |
TPM1 | 240 | 1.7 (4) |
MYBPC3 | 240 | 0.8 (2) |
TNNI3 | 240 | 0.8 (2) |
ACTC | 222 | 0.9 (2) |
LMNA | 208 | 5.3 (11) |
LDB3 | 201 | 0 (0) |
TAZ | 203 | 0 (0) |
PLN | 200 | 0 (0) |
Overall | 264 | 17.4 (46) |
Six variants identified in multivariant cases were not included, to avoid double counting.
Mutation refers to the presence of a clinically significant variant (grade ≥5 by our classification criteria).