Table 3.

Lack of affinity of lisdexamfetamine for a portfolio of abuse-related molecular targets

Receptor or monoamine reuptake transporter target
Benzodiazepine (α1 site)	Glycine  (strychnine insensitive)
Dopamine (non-selective)	Nicotine (α-bungarotoxin insensitive)
GABAA
GABAB
	Opioid (non-selective)
Glutamate  - AMPA  - Kainate  - NMDA	Serotonin (non-selective)
Glycine (strychnine sensitive)	Monoamine reuptake transporter  - DAT  - NET  - SERT

DAT, NET, SERT = dopamine, noradrenaline and 5-HT reuptake transporters, respectively.

AMPA = 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid

NMDA = N-methyl-D-aspartate

GABA = γ-aminobutyric acid.

Displacement was determined in vitro at a lisdexamfetamine concentration of 10μM.

Data on file (Shire Pharmaceuticals, 2003).