Table 1.
Left ventricular echocardiographic parameters in mice after 1 and 4 weeks sham/TAC
| Sham (N = 8) | 1-week TAC (N = 6) | 4-weeks TAC (N = 11) | |
|---|---|---|---|
| HR (bpm) | 541 (31) | 517 (26) | 518 (16) |
| LVEDD (mm) | 3.77 (0.03) | 3.54 (0.14) | 4.17 (0.11)*§ |
| LVESD (mm) | 2.34 (0.14) | 2.39 (0.20) | 3.21 (0.15)*§ |
| IVS (mm) | 0.71 (0.02) | 1.02 (0.04)* | 0.97 (0.06)* |
| PW (mm) | 0.65 (0.02) | 0.92 (0.07)* | 0.99 (0.07)* |
| FS (%) | 39.6 (2.2) | 35.3 (2.6) | 26.2 (1.9)*§ |
| EF (%) | 70.4 (2.8) | 65.2 (3.7) | 51.4 (3.1)*§ |
| Relative WT (mm mm−1) | 0.35 (0.01) | 0.54 (0.03)* | 0.47 (0.03)* |
| LV mass (mg) | 70.8 (2.4) | 102.2 (11.1)* | 120.0 (8.4)* |
bpm, beats per minute; EF, ejection fraction; FS, fractional shortening; HR, heart rate; IVS, interventricular septum; LV, left ventricular; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; N, number of mice; PW, posterior wall; relative WT, relative wall thickness; TAC, transverse aortic constriction.
Data are presented as mean (SEM).
*
P < 0.05 vs. sham.
P < 0.05 vs. 1-week TAC.