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Net metabolic cost in 31 patients with haemophilia as a function of spontaneous walking speed. The severity of joint impairment is arbitrarily classified as “mild” (green symbol, uni/bilateral ankle arthropathy, n = 10), “moderate” (pink symbol, uni/bilateral ankle arthropathy + unilateral knee arthropathy/total knee replacement, n = 10), and “severe” (brown symbol, at least bilateral knee arthropathy/total knee replacement, n = 11).
