Table 1.
Distribution of UPDRS motor item scores by treatment group at baseline and 2-year follow-up
| Levodopa (Mean ± SD) |
Pramipexole (Mean ± SD) |
|||||
|---|---|---|---|---|---|---|
| UPDRS Item (Measure) | Baseline (N=150) |
2-Year (N=131) |
Δ (N=131) | Baseline (N=151) |
2-Year (N=127) |
Δ (N=127) |
| 18 (Speech) | 0.85 ± 0.64 | 0.60 ± 0.68 | −0.24 ± 0.61 | 0.85 ± 0.67 | 0.88 ± 0.73 | 0.03 ± 0.57 |
| 19 (Facial expression) | 1.29 ± 0.70 | 0.92 ± 0.78 | −0.37 ± 0.82 | 1.36 ± 0.74 | 1.24 ± 0.73 | −0.11 ± 0.63 |
| 20a (Tremor at rest: face, lips, chin) | 0.23 ± 0.55 | 0.10 ± 0.35 | −0.13 ± 0.46 | 0.12 ± 0.37 | 0.04 ± 0.20 | −0.06 ± 0.27 |
| 20b (Tremor at rest: R hand) | 0.94 ± 1.01 | 0.55 ± 0.83 | −0.32 ± 0.75 | 0.92 ± 1.04 | 0.50 ± 0.72 | −0.43 ± 0.90 |
| 20c (Tremor at rest: L hand) | 0.73 ± 0.89 | 0.40 ± 0.68 | −0.37 ± 0.75 | 0.79 ± 1.00 | 0.50 ± 0.79 | −0.24 ± 0.72 |
| 20d (Tremor at rest: R foot) | 0.24 ± 0.57 | 0.11 ± 0.40 | −0.10 ± 0.56 | 0.18 ± 0.49 | 0.05 ± 0.23 | −0.14 ± 0.47 |
| 20e (Tremor at rest: L foot) | 0.23 ± 0.55 | 0.13 ± 0.40 | −0.13 ± 0.57 | 0.20 ± 0.48 | 0.10 ± 0.40 | −0.08 ± 0.39 |
| 21a (Action tremor: R) | 0.57 ± 0.74 | 0.34 ± 0.59 | −0.22 ± 0.64 | 0.49 ± 0.68 | 0.30 ± 0.53 | −0.20 ± 0.62 |
| 21b (Action tremor: L) | 0.58 ± 0.65 | 0.33 ± 0.53 | −0.26 ± 0.59 | 0.52 ± 0.63 | 0.33 ± 0.56 | −0.20 ± 0.49 |
| 22a (Rigidity: neck) | 1.06 ± 0.80 | 0.82 ± 0.82 | −0.21 ± 0.69 | 1.09 ± 0.81 | 0.89 ± 0.80 | −0.20 ± 0.78 |
| 22b (Rigidity: R upper extremity) | 1.25 ± 0.82 | 0.83 ± 0.78 | −0.37 ± 0.74 | 1.30 ± 0.78 | 0.99 ± 0.75 | −0.30 ± 0.71 |
| 22c (Rigidity: L upper extremity) | 1.18 ± 0.84 | 0.76 ± 0.75 | −0.42 ± 0.80 | 1.14 ± 0.82 | 0.89 ± 0.80 | −0.21 ± 0.61 |
| 22d (Rigidity: R lower extremity) | 0.80 ± 0.83 | 0.50 ± 0.69 | −0.27 ± 0.78 | 0.78 ± 0.77 | 0.67 ± 0.79 | −0.10 ± 0.72 |
| 22e (Rigidity: L lower extremity) | 0.74 ± 0.82 | 0.54 ± 0.71 | −0.22 ± 0.82 | 0.81 ± 0.83 | 0.68 ± 0.82 | −0.08 ± 0.70 |
| 23a (Finger taps: R) | 1.25 ± 0.97 | 0.79 ± 0.82 | −0.46 ± 0.84 | 1.26 ± 0.85 | 0.84 ± 0.74 | −0.41 ± 0.75 |
| 23b (Finger taps: L) | 1.25 ± 0.95 | 0.87 ± 0.79 | −0.41 ± 0.90 | 1.16 ± 0.90 | 0.85 ± 0.84 | −0.28 ± 0.90 |
| 24a (Hand grips: R) | 0.90 ± 0.84 | 0.51 ± 0.74 | −0.39 ± 0.79 | 0.99 ± 0.78 | 0.77 ± 0.74 | −0.23 ± 0.69 |
| 24b (Hand grips: L) | 1.00 ± 0.88 | 0.63 ± 0.74 | −0.39 ± 0.89 | 0.98 ± 0.87 | 0.79 ± 0.72 | −0.14 ± 0.73 |
| 25a (Hand pronate/supinate: R) | 0.93 ± 0.85 | 0.50 ± 0.75 | −0.42 ± 0.73 | 1.02 ± 0.79 | 0.71 ± 0.76 | −0.30 ± 0.79 |
| 25b (Hand pronate/supinate: L) | 1.00 ± 0.92 | 0.58 ± 0.71 | −0.42 ± 0.82 | 1.00 ± 0.91 | 0.81 ± 0.83 | −0.18 ± 0.87 |
| 26a (Leg agility: R) | 0.71 ± 0.78 | 0.42 ± 0.64 | −0.30 ± 0.79 | 0.87 ± 0.80 | 0.56 ± 0.70 | −0.29 ± 0.77 |
| 26b (Leg agility: L) | 0.84 ± 0.78 | 0.55 ± 0.68 | −0.32 ± 0.86 | 0.83 ± 0.77 | 0.71 ± 0.83 | −0.09 ± 0.70 |
| 27 (Arise from chair) | 0.22 ± 0.42 | 0.12 ± 0.31 | −0.08 ± 0.40 | 0.28 ± 0.47 | 0.23 ± 0.38 | 0.01 ± 0.42 |
| 28 (Posture) | 0.69 ± 0.62 | 0.51 ± 0.60 | −0.17 ± 0.61 | 0.75 ± 0.66 | 0.67 ± 0.62 | −0.01 ± 0.55 |
| 29 (Gait) | 0.61 ± 0.57 | 0.31 ± 0.44 | −0.29 ± 0.50 | 0.65 ± 0.58 | 0.50 ± 0.56 | −0.13 ± 0.49 |
| 30 (Postural stability) | 0.28 ± 0.55 | 0.13 ± 0.35 | −0.09 ± 0.45 | 0.29 ± 0.52 | 0.18 ± 0.42 | −0.09 ± 0.46 |
| 31 (Body bradykinesia) | 1.59 ± 0.67 | 1.00 ± 0.80 | −0.59 ± 0.81 | 1.69 ± 0.72 | 1.30 ± 0.76 | −0.37 ± 0.70 |
| 18–31 (Standard Motor UPDRS) | 21.97 ± 9.64 | 13.85 ± 8.98 | −8.12 ± 8.47 | 22.27 ± 9.16 | 16.97 ± 8.89 | −4.73 ± 7.47 |
| 18–31, excl. 22 & 30 (Modified Motor UPDRS) | 16.66 ± 7.42 | 10.27 ± 6.91 | −6.30 ± 7.40 | 16.85 ± 7.04 | 12.69 ± 6.66 | −3.74 ± 5.90 |
UPDRS, Unified Parkinson’s Disease Rating Scale; SD, standard deviation; R, right; L, left.