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. Author manuscript; available in PMC: 2013 May 29.
Published in final edited form as: Curr Opin Hematol. 2012 May;19(3):176–183. doi: 10.1097/MOH.0b013e3283523e90

Figure 2. Heterotypic cell-cell interactions in vascular development.

Figure 2

A. Macrophages mediate bridging and connection between tip-cells in the retina and central nervous system.

B. Pericyte contact with endothelial cells in the CNS induces cellular changes that allow proper blood brain barrier function.

C. Deletion of Jag1 in the portal vein mesenchyme disturbs the development of intrahepatic bile ducts. This is an example of instructive signaling of vascular cells to the adjacent parenchyma.

D. Preceding angiogenesis is required for proper adipocyte differentiation.