Fig. 3.

MDSC from Panc02-bearing mice suppress CD8⁺ and CD4⁺ T-cell responses. CD11b⁺Gr1⁺ cells were purified from the spleens of Panc02-bearing mice. a Pmel T cells were cultured with gp100_25-33 peptide alone, or at a 1:3 ratio with purified Gr1⁻ or Gr1⁺ cells. Proliferation was measured after 72 h. b OT-II T cells were cultured with DC pulsed with OVA_323-339 peptide alone, or at a 1:10 ratio with purified Gr1 − or Gr1 + cells. Proliferation was measured after 72 h. *p < 0.01