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. Author manuscript; available in PMC: 2013 Sep 28.
Published in final edited form as: Circ Res. 2012 Aug 7;111(8):1027–1036. doi: 10.1161/CIRCRESAHA.112.277145

Figure 2. TMEM16A knockdown reduces swelling-activated Cl− currents in arterial smooth muscle cells.

Figure 2

A, Representative Western blot illustrating that TMEM16A siRNA reduced TMEM16A expression in cerebral arteries. B, Mean data of the effect of TMEM16A siRNA on TMEM16A (n=9), TRPC6 (n=4), TRPM4 (n=5), and TRPP2 (n=9) protein. * indicates P<0.05 when compared to 250 mOsm TMEM16A siRNA. C, Exemplary recordings illustrating that TMEM16A knockdown attenuates swelling-activated Cl− currents in smooth muscle cells. D, Mean data. Control siRNA: 300 mOsm/L, n=8; 250 mOsm/L, n=8. TMEM16A siRNA: 300 mOsm/L, n=9; 250 mOsm/L, n=10.