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. Author manuscript; available in PMC: 2014 Apr 25.

Published in final edited form as: J Med Chem. 2013 Apr 15;56(8):3346–3366. doi: 10.1021/jm400157e

Scheme 3 — Synthesis of tri-substituted compounds 10a–d, 12a–b and 14a–c. a

Reagents and conditions: (a) [Pd] catalyst, Na₂CO₃, toluene/water (1:1), reflux, 24h; (b) BBr₃, CH₂Cl₂, −20 °C to r.t., 4h; (c) NBS, THF/AcOH (1:1), r. t., 12h. ^a See footnote a in Scheme 1.

Scheme 3 — Synthesis of tri-substituted compounds 10a–d, 12a–b and 14a–c. a

Reagents and conditions: (a) [Pd] catalyst, Na₂CO₃, toluene/water (1:1), reflux, 24h; (b) BBr₃, CH₂Cl₂, −20 °C to r.t., 4h; (c) NBS, THF/AcOH (1:1), r. t., 12h. ^a See footnote a in Scheme 1.