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. Author manuscript; available in PMC: 2014 Apr 25.
Published in final edited form as: J Med Chem. 2013 Apr 15;56(8):3346–3366. doi: 10.1021/jm400157e

Figure 3.

Figure 3

Comparisons of ERα and ERβ binding affinities of congeneric bisphenolic thiophene and furan-core ER ligands. In each table, the RBA values are given for binding to ERα or [ERβ] for the various biaryl thiophenes and furans we have studied. The top tables are for the alternate-substituted systems and the bottom tables for the adjacent-substituted systems. The disposition of the aryl groups with respect to the heteroatom (S or O) is indicated by the numbers in parentheses, which are color coded to enable reference to be made between the structures and the appropriate columns in the tables.