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. Author manuscript; available in PMC: 2014 Apr 25.
Published in final edited form as: J Med Chem. 2013 Apr 15;56(8):3346–3366. doi: 10.1021/jm400157e

Figure 4. Activity profile of ERα selective compounds.

Figure 4

HepG2 cells were transfected with 3xERE-luc and expression plasmids for ERα or ERβ, and then dispensed in 384-well plates. The next day cells were treated with the indicated compounds for 24 hr and assayed for luciferase activity. Compound with ERα (red solid line), with ERβ (blue solid line); estradiol with ERα (red dashed line, panel B only), with ERβ (blue dashed line, panel B only); ICI with ERβ (black line, panel C only)