Table 2.

ERα and ERβ relative binding affinity (RBAs) of compounds 10a–d, 12a–b and 14a–c.^a

	10a–d, 12a,b			14a–c
entry	cmpd.	core	R	ERαb	ERβb	β/α
1	10a		H	0.95 ± 0.16	1.6 ± 0.2	1.7
2	10b		2-Me	5.15 ± 0.44	4.8 ± 0.6	0.92
3	10c		2-F	9.3 ± 1.1	20.6 ± 4.1	2.2
4	10d		2-Cl	10.4 ± 1.2	5.41 ± 0.81	0.52
5	12a		2-F	1.88 ± 0.28	2.02 ± 0.57	1.1
6	12b		2-Cl	3.65 ± 0.41	3.01 ± 0.74	0.83
7	14a		H	1.79 ± 0.23	0.47 ± 0.07	0.26
8	14b		2-F	6.35 ± 0.26	0.98 ± 0.02	0.15
9	14c		2-Cl	85.7 ± 2.5	6.0 ± 1.6	0.07

^aSee footnote a in Table 1.

^bSee footnote b in Table 1.