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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Crit Care Med. 2013 Apr;41(4):1075–1085. doi: 10.1097/CCM.0b013e318275d1f9

Figure 4. Lymphocyte activation status.

Figure 4

A. On day 1 following injury, the number of activated (CD69+) splenic CD8+ Cytoxic T and CD19+ B cells were increased in the PT model. In addition, only PT increased the number of CD69+ activated CD4+ T helper and CD19+ lymphocytes in the bone marrow. (*p<0.05 One-way ANOVA). Additionally, the PT model was significantly different from TH and H+FFx in the splenic CD19+ B cells and the bone marrow CD69+ activated CD4+ T helper cells († p<0.05 One-way ANOVA, Tukey’s post-hoc). B. On day 3, PT, TH, and H+FFx all induced a loss of CD4+ T helper cells and cytotoxic CD8+ T cells in the blood (* p<0.0001, p=0.0088 One-way ANOVA, Tukey’s Post-hoc). However, only PT also caused a significant increased activation of the remaining circulating CD4+ T helper lymphocytes (CD69+ and CD25+)(†p=0.0015, p<0.0001, p<0.05 One-way ANOVA, Tukey’s post-hoc test).