Table 1.

Performance of DFE-alpha under its two demographic models

Simulation parameters				DFE-alpha (constant)			DFE-alpha (step-change)
sb	α	γ	β	α	γ	β	α	γ	β	ξ	t
—	0.00	448	0.2	0.12	297	0.26	0.00	703	0.21	5.0	6.2
0.001	0.05	434	0.2	0.20	264	0.27	0.07	676	0.21	5.0	5.4
0.001	0.09	437	0.2	0.22	288	0.26	0.09	914	0.20	8.8	5.2
0.001	0.18	441	0.2	0.27	265	0.27	0.15	754	0.21	8.8	5.4
0.001	0.28	422	0.2	0.40	276	0.27	0.29	1,055	0.20	10.0	4.6
0.001	0.37	836	0.2	0.50	354	0.28	0.41	1,250	0.21	10.0	4.7
0.001	0.49	1,638	0.2	0.57	532	0.29	0.48	2438	0.21	10.0	4.2
0.01	0.06	424	0.2	0.24	233	0.27	0.11	635	0.21	5.0	4.9
0.01	0.09	424	0.2	0.26	217	0.29	0.12	675	0.22	10.0	4.7
0.01	0.18	381	0.2	0.40	152	0.31	0.24	654	0.21	10.0	3.5
0.01	0.27	339	0.2	0.49	109	0.34	0.31	618	0.21	10.0	2.8
0.01	0.36	652	0.2	0.58	158	0.35	0.43	1,113	0.22	10.0	2.6
0.01	0.47	1,154	0.2	0.68	182	0.38	0.53	1,802	0.22	10.0	2.1

Each row denotes a particular simulation run with the parameters specified in the left four columns. The average strength of purifying selection was calculated from the mean of the DFE used in the simulation and inferred from heterozygosity at synonymous sites. The middle three columns show the estimates from DFE-alpha under the demographic model with constant population size. The last five columns show the estimates under the demographic model with a single population size change. is the inferred ratio between present and ancient population size; t is the estimated time since the population size change in units of generations.