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Liquid chromatography traces (Left) of berninamycin A (Upper Right) expression from the natural producer S. bernensis UC 5144 and the heterologous host S. lividans/pSET152+bern (red peak); synthesis of an altered 35-membered ring macrocycle (Lower Right) from heterologous host S. venezuelae/pSET152+bern (blue peak). The stereochemistry shown for this latter metabolite is assumed based on the structure of berninamycin A and its prepeptide and has not been confirmed spectroscopically.
