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. 2013 May 6;110(21):8726–8731. doi: 10.1073/pnas.1302167110

Fig. 1.

Fig. 1.

Differential sensitivity of KCNQ openers to muscarinic receptor modulation in the hippocampus neurons. (A) Action potential spikes elicited by 1-s current injections for control (no drug), M receptor agonist oxotremorine M, Oxo-M + retigabine and Oxo-M + ZnPy. (B and C) Summary of action potential spikes elicited during 1-s current injections. Current injection varied from 0 pA to 80 pA in 10-pA increments. Asterisks indicate significant difference (*P < 0.05; **P < 0.01; n = 4–6). (D and E) Resting membrane potential and spontaneous firing of hippocampal neurons. Time courses of Oxo-M and that supplemented with either retigabine or ZnPy are as indicated. Concentrations used in the experiments are 5 μM for Oxo-M and 10 μM for both retigabine and ZnPy.