Table 1.
Patient and isolate details per clonal cluster group
| Parameter | All (n = 594) | CC199 (n = 233) | CC320 (n = 239) | CC172 (n = 41) | Other STs (n = 81) | P value |
|---|---|---|---|---|---|---|
| Median age in mo (range) | 15.0 (0–250.5)a | 15.5 (0–250.5) | 15.3 (0.2–186.7) | 8.4 (0.32–121.2) | 16.4 (0.23–218.5)a | <0.002d |
| Race | ||||||
| Black | 167 (28.4)h | 66 (28.8) | 47 (19.8) | 26 (63.4) | 28 (34.6) | |
| Caucasian | 259 (44.1) | 81 (35.4) | 141 (59.0) | 11 (26.8) | 26 (32.1) | <0.0001e |
| Hispanic | 96 (16.3) | 56 (24.5) | 26 (11.0) | 1 (2.4) | 13 (16.1) | |
| Other/unknown | 72 (12.1) | 30 (11.4) | 25 (9.7) | 3 (7.3) | 14 (17.3) | |
| No. (%) of males | 337 (57.0)c | 138 (59.2) | 123 (51.9)b | 29(72.5)a | 47/81 (58.0) | 0.07 |
| Diagnosis | ||||||
| Meningitis | 58 (9.8) | 25 (10.7) | 21 (8.8) | 3 (7.3) | 9 (11.1) | |
| Bacteremia | 198 (33.3) | 83 (35.6) | 58 (24.3) | 20 (48.8) | 37 (45.7) | |
| Pneumonia | 214 (36.0) | 86 (36.9) | 88 (36.8) | 14 (34.2) | 26 (32.1) | |
| Bone and joint infections | 24 (4.0) | 9 (3.9) | 10 (4.2) | 2 (4.9) | 3 (3.7) | |
| Mastoiditis | 74 (12.5) | 19 (8.2) | 50 (20.9) | 1 (2.4) | 4 (4.9) | <0.0001f |
| Cellulitis/abscess | 17 (2.9) | 7 (3.0) | 9 (3.8) | 1 (2.4) | 0 | |
| Other | 9 (1.5) | 4 (1.7) | 3 (1.3) | 0 | 2 (2.5) | |
| Center | ||||||
| Chicago | 38 (6.4) | 16/38 (42.1) | 19/38 (50.0) | 0 | 3/38 (7.9) | |
| Columbus | 98 (16.5) | 30/98 (30.6) | 54/98 (55.1) | 0 | 14/98 (14.3) | |
| Houston | 182 (30.6) | 83/182 (45.6) | 71/182 (39.0) | 3/182 (1.6) | 25/182 (13.7) | |
| Little Rock | 90 (15.2) | 20/90 (22.2) | 32/90 (35.6) | 32/90 (35.6) | 6/90 (6.7) | <0.0001g |
| Los Angeles | 22 (3.7) | 13/22(59.1) | 4/22 (18.2) | 1/22 (4.5) | 4/22 (1.8) | |
| Pittsburgh | 69 (11.6) | 19/69 (27.5) | 33/69 (47.8) | 4/69 (5.8) | 16/69 (23.2) | |
| San Diego | 54 (9.1) | 31/54 (57.4) | 12/54 (22.2) | 1/54 (1.9) | 10/54 (18.5) | |
| Winston-Salem | 41 (6.9) | 21/41 (51.2) | 14/41 (34.1) | 0 | 6/41 (14.6) |
One missing data point.
Two missing data points.
Three missing data points.
Patients with CC172 isolates (8.4 [range, 0.32 to 121.2] months) versus patients with other isolates (15.4 [range, 0 to 250.5] months) (Kolmogorov-Smirnov test).
Caucasian patients with CC320 isolates (141/239, 59.0%) versus other isolates (118/355, 33.2%) (Fisher's exact test).
Patients with mastoiditis caused by CC320 isolates (50/239, 20.9%) versus other isolates (24/355, 6.8%) (Fisher's exact test).
CC172 isolates obtained from patients from Arkansas Children's Hospital, Little Rock (32/90, 35.6%), versus other patients (9/504, 1.8%) (Fisher's exact test).
Unless noted otherwise, all values are number (percentages) of patients.