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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Neuropharmacology. 2013 Mar 27;71:1–9. doi: 10.1016/j.neuropharm.2013.03.009

Fig. 6. L-cysteine prevents AS, but not SNAP inhibition of carrageenin-induced mechanical hyperalgesia.

Fig. 6

A - Rats were pre treated with L-cysteine (16.7, 50 and 150 µg/paw, 30 min) before AS or vehicles (as in Fig. 1B), and after additional 15 min rats received carrageenin (100 µg/paw) stimulus. B - Rats were pre treated with SNAP (200 µg/paw, 30 min) before L-cysteine or vehicles (as above), and after additional 15 min rats received carrageenin (100 µg/paw) stimulus. Mechanical hyperalgesia was evaluated 3 and 5 h after stimulus. Vehicles were indicated as zero. n = 6 rats per group per experiment, representative of two separated experiments. *P<0.05 compared with the negative control – saline + vehicle (vehicle not indicated), #P<0.05 compared with positive + vehicle (vehicle not indicated) control group. **P<0.05 compared with AS treatment and the lower dose of L-cysteine. One-way ANOVA followed by Tukey’s t test.