Table 5.
Comparison of receiver operating characteristic curves for serum AFP, miRNA-122a, and the combination of AFP and miRNA-122a
| AUC | 95% CI | Sensitivity (%) | Specificity (%) | P value | |
|---|---|---|---|---|---|
| miRNA-122a and AFP | 0.943 | 0.897–0.973 | 87.1 | 98.8 | <0.0001a |
| miRNA-122a | 0.707 | 0.632–0.774 | 70.6 | 67.1 | <0.0001b |
| AFP | 0.935 | 0.887–0.967 | 85.9 | 98.8 | 0.4359c |
Notes:
a
miRNA-122a and AFP ~ miRNA-122a;
b
miRNA-122a ~ AFP;
c
miRNA-122a and AFP ~ AFP.
Abbreviations: AFP, alfa-fetoprotein; AUC, area under the concentration-time curve; CI, confidence interval.