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. 2013 Feb;33(3):605–621. doi: 10.1128/MCB.01053-12

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Fig 4 — Influence of hAsf1a and hAsf1b tails on the functions of the yAsf1 and hAsf1 cores. (A) Human tails enhance silencing at TELVIIL::URA3 in a cac1Δ background. Strains: ROY1172 (ASF1 CAC1), ROY1171 (ASF1 cac1Δ), BKD185 (yAsf1-myc cac1Δ), BKD198 (yAsf1-atail cac1Δ), BKD194 (yAsf1-btail cac1Δ), and ROY1169 (asf1Δ cac1Δ). (B) Influence of hAsf1a, hAsf1b, and hAsf1a/b and hAsf1b/a chimeras on silencing. (Top) ROY1172 (ASF1 CAC1), ROY1171 (ASF1 cac1Δ), BKD185 (yAsf1 cac1Δ), BKD200 (hAsf1a cac1Δ), BKD235 (hAsf1a-btail cac1Δ), BKD198 (yAsf1-atail cac1Δ), and ROY1169 (asf1Δ cac1Δ). (Bottom) ROY1172 (ASF1), ROY1171 (cac1Δ), BKD185 (yAsf cac1Δ), BKD202 (hAsf1b cac1Δ), BKD196 (hAsf1b-atail cac1Δ), BKD194 (yAsf1-btail cac1Δ), and ROY1169 (asf1Δ cac1Δ). (C) Sensitivity of hAsf1a, hAsf1b, and hAsf1a/b and hAsf11b/a chimeras to DNA-damaging and replicational-stress-inducing drugs (100 mM HU, 0.01% MMS, or 5 μg/ml zeocin). (Top) ROY1172 (ASF1), BKD187 (yAsf1), BKD188 (yAsf1), BKD135 (hAsf1a), BKD136 (hAsf1a), BKD130 (hAsf1b), BKD131 (hAsf1b), and ROY1170 (asf1Δ). (Bottom) ROY1172 (ASF1), BKD187 (yAsf1), BKD188 (yAsf1), BKD144 (hAsf1a-btail), BKD146 (hAsf1a-btail), BKD149 (hAsf1b-atail), BKD150 (hAsf1b-atail), and ROY1170 (asf1Δ).