Table 1.
Baseline demographics, illness history, and baseline illness severity
| |
Placebo |
Olanzapine |
|---|---|---|
| (N = 52) | (N = 104) | |
| Female gender, n (%) |
27 (51.9) |
63 (60.6) |
| Age in years, mean (SD) |
36.3 (9.5) |
40.0 (11.0) |
| Age in years at onset of BD, mean (SD) |
29.1 (8.8) |
33.1 (10.9) |
| Prior episodes, mean (SD) |
|
|
| Manic |
3.02 (3.07) |
3.32 (4.46) |
| Depressive |
3.77 (3.35) |
4.54 (5.69) |
| Mixed |
0.23 (0.70) |
0.13 (0.48) |
| Weight in kg, mean (SD) |
64.02 (12.14) |
59.04 (12.35) |
| Illness severity scores, mean (SD) |
|
|
| MADRS total |
28.62 (8.01) |
29.00 (6.15) |
| YMRS total |
0.85 (1.32) |
0.88 (1.32) |
| HAMD-17 total |
22.69 (4.08) |
23.10 (3.78) |
| CGI-BP |
|
|
| Depression |
4.23 (0.73) |
4.35 (0.75) |
| Mania |
1.02 (0.14) |
1.03 (0.17) |
| Bipolar | 4.10 (0.87) | 4.17 (0.86) |
Abbreviations: BD = bipolar disorder; CGI-BP = Clinical Global Impressions-Bipolar Version Severity of Illness; HAMD-17 = Hamilton Depression Rating Scale-17 items; MADRS = Montgomery-Åsberg Depression Rating Scale; SD = standard deviation; YMRS = Young Mania Rating Scale.