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. 2013 Apr 30;32(1):24. doi: 10.1186/1756-9966-32-24

Table 2.

Effects of HU compounds on proliferation of several cancer cell lines

    Cell lines IC50[μM]
Cpd
 R1
 R2
 R3
 R4
 M14
 MCF-7
 PC3
 A498
 A375
I
 H
 H
 H
 Inline graphic
 >100
 >100
 >100
 >100
 >100
II
 n-hexyl
 H
 H
 Inline graphic
 23 ± 0.12
 28.13 ± 0.07
 41 ± 0.20
 34.91 ± 3.82
 >100
III
 H
 H
 H
 Inline graphic
 >100
 >100
 >100
 >100
 >100
IV
 n-hexyl
 H
 H
 Inline graphic
 45.6 ± 0.20
 37.3 ± 0.34
 38 ± 0.12
 28.8 ± 0.04
 30.7 ± 0.12
V
 n-hexyl
 H
 H
 H
 7.0 ± 0.10
 18.7 ± 0.06
 24.3 ± 0.20
 19.8 ± 0.02
 12.9 ± 0.06
VI
 H
 n-hexyl
 H
 H
 -
 >100
 >100
 >100
 >100
VII
 H
 n-hexyl
 CH3
 H
 -
 >100
 >100
 >100
 >100
VIII
 H
 H
 CH3
 n-hexyl
 -
 >100
 >100
 >100
 >100
IX
 -CH3
 n-butyl
 CH3
 H
 24.5 ± 0.15
 12 ± 0.03
 17.9 ± 0.20
 51 ± 0.02
 17.6 ± 0.05
X
 H
 n-butyl
 CH3
 H
 35 ± 0.64
 >100
 >100
 >100
 >100
XI
 H
 n-butyl
 H
 H
 >100
 >100
 >100
 >100
 >100
XII
 -CH3
 n-hexyl
 CH3
 H
 10.7 ± 0.15
 16.2 ± 0.03
 18.8 ± 0.03
 >100
 21.0 ± 0.04
XIII
 H
 n-hexyl
 CH3
 H
 14.1 ± 0.15
 13.9 ± 0.04
 20.1 ± 0.20
 >100
 18.1 ± 0.04
XIV
 H
 n-hexyl
 H
 H
 >100
 >100
 >100
 >100
 >100
H331   15.0 ± 0.09 24.5 ± 0.15 32.0 ± 0.15 34.6 ± 0.23 21.8 ± 0.03

Cell viability was assessed through MTT assay. Data represent the mean ± SD values of three independent determinations performed in triplicate. A375, M14, human melanoma cells; MCF-7, human breast cancer cells; PC3, Human prostate cancer cell line, A498, Human renal cancer cell line.