Table 6.

Possible indications for the use of radiotherapy in adults

Recommendation	Grade
Isolated “Unresectable” lesion:	C2
if a resection would significantly compromise anatomic function, e.g. odontoid peg, CNS
Recurrent or progressive lesion:	C2
In multifocal or multisystem disease only in case of minor response to standard systemic therapy
Adjuvant treatment following marginal or incomplete resection: especially in single system bone disease with soft tissue involvement	C2