Table 9.

Recommendations for follow-up

Test	Frequency	Grade
SS-LCH And No Disease Activity
History (especially of thirst, polyuria, cough, dyspnea, bone pain, skin changes, neurological symptoms)	• Every clinic visit	D2
Clinical assessment, blood count and blood chemistry (as described in baseline diagnostics), ultrasound	• End of therapy	D2
	• every 6 month (for the next 2 years)
	• then once a year (for at least 3 years)
Chest XR	• annually (for at least 3 years)	D2
After MS-LCH And With No Disease Activity
History (especially of thirst, polyuria, cough, dyspnea, bone pain, skin changes, neurological symptoms)	• Every clinic visit	D2
Clinical assessment, blood count and blood chemistry (as described in baseline diagnostics), ultrasound	• End of therapy	D2
	• every 3 month (for the next 2 years)
	• every 6 month (for the next 3 years)
	• then once a year (for at least 5 years)
Chest XR	• annually (for at least 3 years)	D2
TSH, freeT4	• Once a year (until end of routinely follow up)	D2
Patients With Active Disease
Diagnostic procedures are depending on the site of organ involvement	Frequency is depending on rates and velocity of recurrences	D2
Patients With pLCH
History (in case of non-pulmonary symptoms: look for MS LCH, see Table 4)	• Every clinic visit	D2
Diagnostic procedures are depending on symptoms und course of PLCH (baseline: Chest X-ray, lung function (+DCLO)	• End of therapy	D2
	• every 6 month (for the next 2 years)
	• then once a year (for at least 5 years)