Table 1.

Enriched pathways in disjoint catalog analysis

	Human		Mouse
	Cross-alignment	Cross hybridization	Cross-alignment	Cross hybridization
1	Cytoskeleton remodeling: keratin filaments	Protein folding and maturation: POMC processing	Cytoskeleton remodeling: neurofilaments	Neurophysiological process: Dopramine D2 receptor transactivation of PDGFR in CNS
2	Signal transduction: cAMP signaling	Normal and pathological: TGF-beta mediated regulation of cell proliferation	DNA damage: ATM/ATR regulation of G2M checkpoint	Transcription role of heterochromatin protein 1 (HP1) family in transcriptional silencing
3	Development: regulation of epithelial to mesenchymal transition (EMT)	Cytoskeleton remodeling: TGF, WNT and cytoskeletal remodeling	Cell cycle: role of Nek in cell cycle regulation	Development: hedgehog and PTH signaling pathways in bone and cartilage development
4	Cell adhesion: gap junctions	Signal transduction, Erk interaction: inhibition of Erk	Cell cycle: spindle assembly and chromosome separation	Cytoskeleton remodeling: neurofilaments
5	Development: transcription regulation of granulocyte development	Development: melanocyte development ang pigmentation	Development: hedgehog signaling	Development: Gastrin in differentiation of the gastric mucosa
6	Cytoskeleton remodelling: regulation of actin cytoskeleton by Rho GTPases	Translation: non-genomic (rapid) action of androgen receptor	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)	Blood coagulation: Blood coagulation
7	Cell adhesion: Histamine H1 receptor signlaing in the interruption to cell barrier integrity	G-protein signaling : Rap1A regulation pathway	Development: FGFR signaling pathway	Development thrombopotein-regulated cell processes
8	Development: beta-adrenergic receptors signaling via cAMP	Development: GDNF family signaling	Muscle contraction: regulation of eNOS activity in endothelial cells	Neurophysiologiacal process: ACM regulation of nerve impulse
9	Cytoskeleton remodeling: reverse signaling by Ephrin B	DNA damage: role of SUMO in p53 regulation	GFTR folding and maturation (normal and CF)	Development: WNT5 signaling
10	Regulation of lipid metabolism: regualtion of lipid metabolism by niacin and isoprenaline	Muscle contaction: relaxin signaling pathway	DNA damage: role of SUMO in p53 regulation	Transport: Alpha-2 energenic receptor regulation of Ion channels

Enriched GeneGo pathway maps for human and mouse. Gene lists for pathway analsysis were obtained from the disjoint gene catalog analysis for both cross-hybridization (microarrays) and cross-alignment (RNA-Seq).