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. 2013 May 29;8(5):e64152. doi: 10.1371/journal.pone.0064152

Figure 1. Effect of dietary WCHF in mice with DSS-induced acute colitis.

Figure 1

Colitis was induced by providing 2% DSS in drinking water for 9 days. Mice were simultaneously orally administered with vehicle (1% Tween 80) or WCHF (50 mg/kg body weight) respectively for 7 days, followed by DSS treatment for 9 days (test mouse were administered continuously with test sample during the DSS treatment). Changes of (A) relative body weight, (B) disease activity index, (C) colon length, (D) histological section, (E) histological score and (F) myeloperoxidase activity are shown. Data are expressed as mean ± SD. (n = 5–6). (G) Effect of hot water extract of fresh W. chinensis (WCHF) on expression of specific cytokines and T cells response in WCHF-treated and DSS-induced colitis mice. (H) Effect of WCHF extract (100 µg/ml, 200 µg/ml and 400 µg/ml) on ex-vivo expression of IL-12 and TGF-β from mouse DCs in culture. Representative H&E-stained middle tissue sections of colons under 40× and 100× magnification. *P<0.05, **P<0.005, ***P<0.001, significant difference compared with the control group. # P<0.05, ## P<0.005, ### P<0.001, significant difference compared with the DSS group.