Figure 6. Somatic efficacy of 15-RVD TALEN compared with other reported TALEN scaffolds, ZFN and CRISPR/Cas9.

Plot of somatic mutation rates in zebrafish genome editing using ZFNs [8], [32], TALENs [25], [29], [30], [32] and CRISPR/Cas9 [46] from representative publications together with 15-RVD TALENs from this study. *Only Homo-dimeric TALENs were compared. ^†Only 15-RVD TALENs with spacer lengths between 13–20 bp and a T nucleotide preceding the TALEN binding site were included.