Table 1.
Effect of cinnamic acid on cell cycle of HT-144 and NGM cells after 48 h exposure
|
Cell line |
Cell cycle phases |
Control groups |
Treated groups |
|
|---|---|---|---|---|
| 0.4 mM | 3.2 mM | |||
| HT-144 |
Hypodiploid cells |
13.80 ± 3.49 |
15.38 ± 0.86 |
25.78 ± 2.85a |
| |
G0/G1 phases |
42.90 ± 4.37 |
45.12 ± 2.32 |
47.99 ± 5.30 |
| |
S phase |
16.08 ± 2,49 |
12.22 ± 2.01 |
6.35 ± 1.21b |
| |
G2/M phases |
18.69 ± 4.10 |
19.95 ± 1.95 |
15.07 ± 2.04 |
| |
Polyploid cells |
9.16 ± 3.14 |
7.80 ± 2.43 |
5.19 ± 1.84 |
| NGM |
Hypodiploid cells |
11.25 ± 3.88 |
8.51 ± 3.10 |
43.31 ± 5.46b |
| |
G0/G1 phases |
64.81 ± 3.43 |
64.72 ± 7.43 |
40.46 ± 3.94b |
| |
S phase |
5.59 ± 1.56 |
4.48 ± 1.43 |
2.24 ± 1.01 |
| |
G2/M phases |
13.67 ± 1.43 |
16.82 ± 2.36 |
10.93 ± 3.65 |
| Polyploid cells | 4.93 ± 1.45 | 5.70 ± 1.27 | 3.21 ± 1.46 | |
The numbers represent the frequency of cells (%) in each phase of the cell cycle according to DNA quantification by flow cytometry. Results are showed as Mean ± SD.
a Significantly different (p≤0.01) from control group and 0.4 mM treated group.
b Significantly different (p≤0.05) from control group.