Figure 5. Independence of sequence and functional properties in predicting toxicity.

Prediction accuracy (ROC-AUC) of overexpression toxicity from sequence (positively charged residue count, pI, and length) and functional features (transcription factor, regulation and catalytic function information). Combining sequence and functional features increases the predictive power indicating at least their partial independence. TF = transcription factors, pI = Isoelectric point.