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. 2013 May 29;8(5):e64341. doi: 10.1371/journal.pone.0064341

Figure 1. Exaggerated CF lung responses to bleomycin are attenuated by vardenafil.

Figure 1

a) Soluble collagen content in homogenized unlavaged lungs; b) lymphocyte counts, c) CCL-2, d) IL-6, and e) TGF-β1 in bronchoalveolar lavage (BAL); and f) TIMP-1 in homogenized unlavaged lungs from CF mice homozygous for the F508del mutation and from wild-type (WT) mice 10 days after deposition into the lungs by pharyngeal aspiration of a single dose of 0.015 U bleomycin (Bleo). In case of simultaneous treatment with bleomycin and vardenafil, animals were given a first intraperitoneal injection of 0.14 mg/kg vardenafil (Vard) on the day before the bleomycin dose and every day thereafter until the day before sampling. Values are means ± SEM of 5 animals per group from a representative experiment selected from a series of 3 experiments with similar results. *: P<0.05; **: P<0.01; *** P<0.001 for comparison of mean values.