Figure 2. Lung histological responses to bleomycin are attenuated by vardenafil.

Lung histological sections of wild-type (a,b,e,f,i,j) and CF mice homozygous for the F508del mutation (c,d,g,h,k,l) 10 days after treatment with saline (NaCl; a–d), bleomycin (Bleo; e–h) or bleomycin and vardenafil (Bleo+Vard; i–l) were stained with hematoxylin and eosin (a,c,e,g,i,k); impregnated with silver (b,d,f,h,j,l) or stained with Masson’s trichrome (inserts). Bars, 100 µm in panels a,c,e,g,i,k; 20 µm in panels b,d,f,h,j,l; and 40 µm in inserts. Representative micrographs from 5 mice per group.