Figure 8.

Givinostat reduces Evans blue uptake in diaphragms of mdx mice. (A) Representative images of Evans blue uptake in diaphragm transverse sections of CTR-, TSA-, or givinostat-treated mdx mice (givinostat 1 mg/kg/d = ITF1; givinostat 5mg/kg/d = ITF5; givinostat 10 mg/kg/kg = ITF10). Diaphragms were harvested after a treadmill test at the end of the treatment. Original magnification, 2×. (B) Graph representing Evans blue uptake scored as red area (reported as pixel²) per field. Data are presented as the average ± SEM; n = 2. **p < 0.01.