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A) Observed fibrosis as a function of blood concentration AUC (h/nmol/L) and predicted profile using a one-parameter Hill equation (AUC50 = 512 h/nmol/L, CV% = 38.1). (B) Observed MPO as a function of blood concentration AUC (h/nmol/L) and predicted profile using a one-parameter Hill equation (AUC50 = 632 h/nmol/L, CV% = 35.7).
