Table 2.

VRS-317 PK Parameters in GH-Deficient Adults After a Single Subcutaneous Injection

Dose	Cmax, ng/mL	Tmax, h	AUC0–t, ng·h/mL	AUC0–∞, ng·h/mL	t1/2, h
0.05 mg/kg	92 ± 29	46 ± 27	11,161 ± 3,395	11,706 ± 3,499	68 ± 18
0.10 mg/kg	354 ± 368	44 ± 21	33,365 ± 16,410	33,822 ± 16,343	85 ± 34
0.20 mg/kg	889 ± 606	50 ± 19	86,429 ± 67,201	87,291 ± 67,068	90 ± 50
0.40 mg/kg	1968 ± 676	48 ± 17	241,280 ± 121,549	244,601 ± 125,167	109 ± 57
0.80 mg/kg	2887 ± 1345	82 ± 39	402,541 ± 124,653	407,421 ± 124,915	131 ± 62

Values are means ± SD. The dose proportionality correlation coefficients (log:log) were 0.87 for C_max and 0.93 for AUC_0–t.

Abbreviations: AUC_0–t, area under the curve from time 0 to the last measurable time point; AUC_0-–∞, area under the curve from time 0 to infinity; C_max, maximum concentration; T_max, time to maximum concentration.