Table 4.

Treatment-Emergent Adverse Events Possibly, Probably, or Definitely Related to Study Drug Administration in the Safety Population (n = 50)

	Treatment Group
	Placebo	0.05 mg/kg	0.10 mg/kg	0.20 mg/kg	0.40 mg/kg	0.80 mg/kg
No. subjects	10	8	8	8	8	8
No. subjects with any event	2	1	4	4	7	7
No. events	2	1	2	3	4	6
Headache	0	0	1	1	2	0
Cognitive disorder	1	0	0	0	0	0
Nausea	1	0	0	0	1	0
Arthralgia	0	0	1	0	0	2
Myalgia	0	0	0	0	0	1
Muscle fatigue	0	0	0	0	0	1
Edema	0	0	0	0	0	1
Rash	0	0	0	1	1	0
Generalized pruritus	0	1	0	0	0	0
Paresthesia	0	0	0	1	0	0
Warm skin	0	0	0	0	0	1

Injection site reactions and laboratory events are discussed in the text.